| # | Pitcher | JJ | JI | G | P | SV | IP | H | CP | CL | HR | BB | K | WHIP | EFE |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Junior Fernandez | 1 | 0 | 0 | 0 | 0 | 2.0 | 2 | 0 | 0 | 0 | 0 | 1 | 1.00 | 0.00 |
| 1 | Ryan Helsley | 14 | 0 | 2 | 0 | 3 | 16.1 | 2 | 1 | 0 | 0 | 3 | 27 | 0.31 | 0.00 |
| 1 | Angel Rondon | 1 | 0 | 1 | 0 | 0 | 5.0 | 1 | 0 | 0 | 0 | 3 | 4 | 0.80 | 0.00 |
| 4 | Andre Pallante | 16 | 0 | 0 | 0 | 0 | 22.0 | 20 | 2 | 2 | 1 | 10 | 13 | 1.36 | 0.82 |
| 5 | Miles Mikolas | 9 | 9 | 3 | 2 | 0 | 55.0 | 43 | 13 | 12 | 3 | 11 | 41 | 0.98 | 1.96 |
| 6 | Genesis Cabrera | 18 | 0 | 2 | 1 | 0 | 20.0 | 15 | 6 | 5 | 4 | 6 | 15 | 1.05 | 2.25 |
| 6 | Jake Woodford | 8 | 0 | 1 | 0 | 0 | 16.0 | 13 | 5 | 4 | 1 | 6 | 10 | 1.19 | 2.25 |
| 8 | Packy Naughton | 6 | 1 | 0 | 1 | 0 | 9.1 | 10 | 3 | 3 | 2 | 1 | 8 | 1.18 | 2.89 |
| 9 | Adam Wainwright | 9 | 9 | 5 | 4 | 0 | 52.0 | 48 | 19 | 18 | 5 | 19 | 38 | 1.29 | 3.12 |
| 10 | Dakota Hudson | 9 | 9 | 3 | 2 | 0 | 44.2 | 40 | 17 | 16 | 4 | 23 | 25 | 1.41 | 3.22 |
| 11 | Giovanny Gallegos | 17 | 0 | 0 | 2 | 8 | 16.2 | 13 | 7 | 6 | 1 | 4 | 19 | 1.02 | 3.24 |
| 12 | Drew VerHagen | 8 | 0 | 2 | 0 | 0 | 12.1 | 9 | 6 | 5 | 2 | 8 | 8 | 1.38 | 3.65 |
| 13 | Matthew Liberatore | 2 | 2 | 1 | 0 | 0 | 9.2 | 9 | 4 | 4 | 1 | 5 | 9 | 1.45 | 3.72 |
| 14 | Nick Wittgren | 20 | 0 | 0 | 0 | 0 | 16.2 | 20 | 9 | 9 | 0 | 7 | 7 | 1.62 | 4.86 |
| 15 | Jordan Hicks | 9 | 7 | 1 | 4 | 0 | 28.2 | 20 | 16 | 16 | 3 | 20 | 29 | 1.40 | 5.02 |
| 16 | Kodi Whitley | 12 | 0 | 2 | 0 | 0 | 11.1 | 9 | 7 | 7 | 1 | 6 | 12 | 1.32 | 5.56 |
| 17 | Steven Matz | 9 | 9 | 3 | 3 | 0 | 37.1 | 44 | 25 | 25 | 8 | 8 | 44 | 1.39 | 6.03 |
| 18 | Aaron Brooks | 5 | 0 | 0 | 0 | 0 | 9.1 | 11 | 8 | 8 | 3 | 2 | 7 | 1.39 | 7.71 |
| 19 | T.J. McFarland | 16 | 0 | 0 | 0 | 0 | 17.0 | 24 | 15 | 15 | 4 | 6 | 11 | 1.76 | 7.94 |
| 20 | Jake Walsh | 3 | 0 | 0 | 1 | 0 | 2.2 | 3 | 4 | 4 | 0 | 2 | 5 | 1.88 | 13.50 |
| 21 | Yadier Molina | 1 | 0 | 0 | 0 | 0 | 1.0 | 4 | 4 | 4 | 2 | 0 | 0 | 4.00 | 36.00 |
| 21 | Albert Pujols | 1 | 0 | 0 | 0 | 0 | 1.0 | 3 | 4 | 4 | 2 | 1 | 0 | 4.00 | 36.00 |
