| # | Pitcher | JJ | JI | G | P | SV | IP | H | CP | CL | HR | BB | K | WHIP | EFE |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Junior Fernandez | 7 | 0 | 0 | 0 | 0 | 11.0 | 4 | 0 | 0 | 0 | 3 | 8 | 0.64 | 0.00 |
| 1 | James Naile | 3 | 0 | 0 | 0 | 0 | 4.2 | 2 | 0 | 0 | 0 | 0 | 4 | 0.43 | 0.00 |
| 1 | Angel Rondon | 1 | 0 | 1 | 0 | 0 | 5.0 | 1 | 0 | 0 | 0 | 3 | 4 | 0.80 | 0.00 |
| 4 | Ryan Helsley | 26 | 0 | 4 | 1 | 6 | 32.2 | 10 | 4 | 3 | 1 | 11 | 50 | 0.64 | 0.83 |
| 5 | Genesis Cabrera | 25 | 0 | 3 | 1 | 1 | 31.2 | 21 | 9 | 8 | 5 | 12 | 26 | 1.04 | 2.27 |
| 6 | Zack Thompson | 10 | 1 | 1 | 1 | 1 | 20.0 | 14 | 7 | 6 | 2 | 6 | 14 | 1.00 | 2.70 |
| 7 | Miles Mikolas | 17 | 17 | 5 | 7 | 0 | 106.0 | 83 | 36 | 32 | 11 | 22 | 83 | 0.99 | 2.72 |
| 8 | Giovanny Gallegos | 29 | 0 | 2 | 2 | 9 | 31.0 | 23 | 12 | 10 | 3 | 9 | 37 | 1.03 | 2.90 |
| 9 | Andre Pallante | 24 | 6 | 2 | 4 | 0 | 59.1 | 61 | 20 | 20 | 6 | 22 | 38 | 1.40 | 3.03 |
| 10 | Jake Woodford | 11 | 0 | 1 | 0 | 0 | 20.2 | 18 | 8 | 7 | 1 | 8 | 11 | 1.26 | 3.05 |
| 11 | Adam Wainwright | 16 | 16 | 6 | 6 | 0 | 96.2 | 96 | 36 | 35 | 9 | 27 | 81 | 1.27 | 3.26 |
| 12 | Johan Oviedo | 9 | 1 | 1 | 1 | 0 | 19.0 | 20 | 7 | 7 | 3 | 5 | 18 | 1.32 | 3.32 |
| 13 | Packy Naughton | 14 | 3 | 0 | 2 | 0 | 19.1 | 19 | 9 | 9 | 2 | 4 | 18 | 1.19 | 4.19 |
| 14 | Dakota Hudson | 16 | 16 | 6 | 5 | 0 | 84.0 | 81 | 41 | 40 | 6 | 39 | 46 | 1.43 | 4.29 |
| 15 | Jordan Hicks | 10 | 7 | 1 | 4 | 0 | 30.1 | 22 | 16 | 16 | 3 | 20 | 29 | 1.38 | 4.75 |
| 16 | Jack Flaherty | 3 | 3 | 0 | 0 | 0 | 8.0 | 8 | 6 | 5 | 1 | 9 | 6 | 2.13 | 5.63 |
| 17 | Matthew Liberatore | 5 | 5 | 2 | 1 | 0 | 20.2 | 26 | 13 | 13 | 4 | 11 | 18 | 1.79 | 5.66 |
| 18 | Kodi Whitley | 14 | 0 | 2 | 0 | 0 | 12.2 | 11 | 8 | 8 | 2 | 9 | 12 | 1.58 | 5.68 |
| 19 | Nick Wittgren | 29 | 0 | 1 | 0 | 1 | 29.0 | 35 | 19 | 19 | 1 | 10 | 17 | 1.55 | 5.90 |
| 20 | Steven Matz | 9 | 9 | 3 | 3 | 0 | 37.1 | 44 | 25 | 25 | 8 | 8 | 44 | 1.39 | 6.03 |
| 21 | Drew VerHagen | 17 | 0 | 3 | 1 | 0 | 20.0 | 23 | 16 | 14 | 4 | 13 | 16 | 1.80 | 6.30 |
| 22 | T.J. McFarland | 24 | 0 | 0 | 0 | 0 | 26.2 | 39 | 22 | 22 | 4 | 8 | 16 | 1.76 | 7.43 |
| 23 | Aaron Brooks | 5 | 0 | 0 | 0 | 0 | 9.1 | 11 | 8 | 8 | 3 | 2 | 7 | 1.39 | 7.71 |
| 24 | Jake Walsh | 3 | 0 | 0 | 1 | 0 | 2.2 | 3 | 4 | 4 | 0 | 2 | 5 | 1.88 | 13.50 |
| 25 | Yadier Molina | 2 | 0 | 0 | 0 | 0 | 2.0 | 6 | 4 | 4 | 2 | 0 | 1 | 3.00 | 18.00 |
| 26 | Albert Pujols | 1 | 0 | 0 | 0 | 0 | 1.0 | 3 | 4 | 4 | 2 | 1 | 0 | 4.00 | 36.00 |
